Recently, Taiwanese researchers found that the Enterovirus infection might be associated with the development of Type1 Diabetes.
Tsai- Chung Li, MD, of China Medical University in Taiwan stated online in Diabetologia, “In a demonstration analysis of national insurance data, children younger than age 18 who had been infected with enterovirus were 48% more likely to develop type 1 diabetes.”
Moreover, the researchers stated that, the findings of the study propose that a preventive strategy, such as an effective vaccine against enterovirus infection, might minimize the chances of type 1 diabetes in Taiwan.
Type 1 diabetes is mainly caused by a complex interface between genetic vulnerability, the immune system, and environmental factors. Chung-Li and colleagues stated that, the genetic tendency to type 1 diabetes has been explained, however environmental triggers are less implicit.
The researchers further stated that, it’s become crucial to explore that aspect because type 1 diabetes chances has increased, and genetic factors alone don’t explain the rise.
There are some studies that suggests, the enterovirus infection, which includes Coxsackievirus A, Coxsackievirus B, and echovirus might play a role. They took the data from Taiwan’s national health insurance system for the period of 2000-2007.
Through that time, a total of 570,133 children had an enterovirus infection, and the researchers matched them with 570,133 controls who didn’t have an infection over that time period.
The researchers discovered that, the overall incidence of type 1 diabetes were higher in kids who had been infected by enterovirus (5.73 versus 3.89 per 100,000), for an incidence rate ratio 1.48 of among infected children (95% CI 1.19 to 1.83).
Afterwards, the researchers found with the help of adjusted analyses that enterovirus infection and older age were tied up with a higher risk of type 1 diabetes. Particularly, kids who were older than age 10 had an increased risk of type 1 diabetes (HR 2.18, 95% CI 1.18 to 4.04).
On the other hand, there was no relationship, between type 1 diabetes and either allergic rhinitis or bronchial asthma.
Furthermore, Chung-Li and his colleagues stated that, TEDDY (The Environmental Determinants of Diabetes in the Young) study is ongoing and aims to determine how environmental factors influence the onset of type 1 diabetes in susceptible patients. It has already shown, for instance, that Coxsackievirus B1 is connected with an increased risk of type 1 diabetes in Finland.
Though, the researchers admitted that type 1 diabetes evidently involved a “major genetic component”. Moreover, the observational findings are “solid enough to guide further research on this association,” researchers said.