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Osteoporosis is the main reason for bone pain, breakage and other associated damages especially for senior citizens.
The disease can occur because of hormonal changes, alcoholism, anorexia and kidney disease and other medical conditions.
Researchers may have found a new remedy for osteoporosis and other bone related diseases. It is now going through testing, but could solve the causes of pain for millions of people by directly treating bone structure.
At the Scripps Research Institute, a nonprofit medical research facility, scientists have analyzed the effects of a protein known as PPARG on stem cells of the bone marrow.
PPARG is a protein-coding gene that helps regulate the fat acid storage and glucose metabolism.
Laboratory testing and analysis have helped scientist create a new compound called SR2595 that allows increases of osteoblast formations , a cell type known to form bone.
They did this by combining their knowledge of structural biology and used different approaches to rationally design this new, potentially revolutionary compound.
Researchers claim that a reduced amount of PPARG protein has had significant effects on encouraging bone growth in mice.
Not only this but, since PPARG is influencing stem cells directly ,the possibility of reducing it could have effects on several body organs.
Stem cells have the ability to develop into different cells, including fat and bone tissue. This could mean that controlling the amounts of PPARG using SR2595 could lead to treatments in fat and insulin related diseases like diabetes.
Patrick Griffin who is chair of the Department of Molecular Therapeutics and director of TRI at Scripps Florida said that “These findings demonstrate for the first time a new therapeutic application for drugs targeting PPARy, which has been the focus of efforts to develop insulin sensitizers to treat type 2 diabetes,”
Osteoporosis cases in 2010 were about 22 million women and 5.5 million men only in the European Union and 8 million women and 2 million men in the U.S. Treating this disease could prevent millions of bone fractures every year.
Diabetes which could also be partially treated in the future using SR2595 related medicine, affected around 29 million people only in the U.S. with a suspected 8.1 million people being undiagnosed.
Image Source: scripps.edu