A cure for the dreaded Alzheimer’s might be around the corner, thanks to a new study performed by a team of scientists from the United Kingdom. According to the study by tackling brain inflammation lower the risk of Alzheimer’s.
According to this brand new study conducted by a team of scientists from the Southampton University, one could totally obliterate the harrowing effects of Alzheimer’s progression by inhibiting a neuroreceptor cell called CSF1R.
This highly specialized brain cell is capable of modulating the activity of immune cells inside our brain. Following the study, it would seem that if the CSF1R cells in our brain are inhibited, then out own immune system can kick in, thus protecting the brain from the effects of Alzheimer’s.
In order to see the degree of interactions between this type of immune cells and the brain, the scientists had to set up a little lab experiment. Harvesting cells from healthy patients and from patients suffering from Alzheimer’s, the researchers were able to trace the problem to a series of immune cells called microglia.
By comparing the level of microglia in the two brain tissue sample, the researchers arrived at the following conclusion. Interestingly enough, it would seem that there is an increased number of microglia cells inside the brain tissue harvested from the patient suffering from Alzheimer’s.
Retracing the problem in-depth, the researchers have managed to understand that the activity between the molecules and proteins that are capable of regulating a number of microglia cells inside our brain is directly responsible for the severity of this disease.
According to a new study, tackling brain inflammation lowers the risk of Alzheimer’s. As of now, the researchers managed to trace the problem back to the activity of the molecules which modulates the amount of microglia cells present in our brain.
To see if indeed Alzheimer’s can be stopped simply by using CSF1R inhibitors, the team of British scientists set up another lab experiments, only, this time, it involved mice.
Several lab mice were bred specifically for this purpose, meaning some of them already showed signs of mild cognitive impairment, the first stage of Alzheimer’s. After the mice started showing the first signs of the disease, the researchers fed them CSF1R inhibitors in order to see in there is any change in their condition.
The results of the study proved to be quite vague. Although the rats responded to the treatment, the inhibitor was only capable of reducing the excessive formation of microglia. Unfortunately, the inhibitor had little to no effects on the amyloid plaques, one of Alzheimer’s distinctive sign.
Although the results proved to be quite vague, the researchers were capable of demonstrating that we should be looking towards brain immunity when researching a cure for this neurological disorder.